CaMKII-dependent endoplasmic reticulum fission by whisker stimulation and during cortical spreading depolarization
نویسندگان
چکیده
منابع مشابه
Interplay between Cortical Spreading Depolarization and Seizures.
Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies obser...
متن کاملViral protein targeting to the cortical endoplasmic reticulum is required for cell–cell spreading in plants
Many plant RNA viruses use their nonstructural proteins to target and move through the cortical endoplasmic reticulum (ER) tubules within the plant intercellular junction for cell-to-cell spreading. Most of these proteins, including the triple-gene-block 3 protein (TGBp3) of Potexvirus, are ER membrane proteins. We previously showed that TGBp3 of the Bamboo mosaic potexvirus partitions into tub...
متن کاملNMDA Receptor Stimulation Induces Reversible Fission of the Neuronal Endoplasmic Reticulum
With few exceptions the endoplasmic reticulum (ER) is considered a continuous system of endomembranes within which proteins and ions can move. We have studied dynamic structural changes of the ER in hippocampal neurons in primary culture and organotypic slices. Fluorescence recovery after photobleaching (FRAP) was used to quantify and model ER structural dynamics. Ultrastructure was assessed by...
متن کاملActivity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stress.
The endoplasmic reticulum (ER) is an essential cellular compartment responsible for Ca(2+) sequestration, signaling, protein translation, folding as well as transport. Several acute and chronic disease conditions impair ER function leading to ER stress. To study the impact of ER stress on synaptic transmission we applied tunicamycin (TM) or thapsigargin (TG) to hippocampal neurons, which trigge...
متن کاملMechanisms of Neuronal Swelling during Spreading Depolarization
......................................................................................................................... ii Lay Summary ................................................................................................................ iii Preface .......................................................................................................................... iv Table of
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain
سال: 2018
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awy036